Yale University

Yale Center for Clinical Investigation

Yale Center for Clinical Investigation
2 Church Street South
Suite 414/401
New Haven, CT 06519
United States
Call (203) 737-2760 Email this location
Yale is one of twenty-five Type 1 Diabetes TrialNet International Clinical Centers at the forefront of type 1 diabetes research. Led by our Clinical Center Director and Principal Investigator, Kevan Herold, MD, the TrialNet team at Yale is dedicated to preventing type 1 diabetes and stopping disease progression by preserving insulin production before and after diagnosis.

Our Team

Principal Investigators 
My background and research are in translational immunology. I am interested in understanding the basis for autoimmune diseases and developing new therapies based on our understanding of disease mechanisms. My focus has largely been in the field of autoimmune Type 1 diabetes. The work encompasses basic laboratory work understanding the regulation of autoreactive T cells to clinical trials that involve novel therapeutics. As part of these studies I have also been very interested in analysis of beta cell function in Type 1 diabetes.
Research Coordinators 

Regional Affiliates

Affiliates provide opportunities for people who do not live near Yale. The affiliate sites listed below work with Yale to offer convenient participation in our research programs.

Eastern Maine Medical Center
EMMC-Clinical Research Center, 1 Cumberland Place, Bangor, ME 04401


Joslin Diabetes Center
One Joslin Place, Boston, MA 02215
(888) 813-8669


Danbury Hospital
79 Sandpit Road, Danbury, CT 06810
(203) 749-5754 joann.ahern@wchn.org


Connecticut Children's Medical Center
282 Washington Street, Hartford, CT 06106


Trustees of Dartmouth College and the constituent members of Dartmouth Hitchcock Med
One Medical Center Drive, Lebanon, NH 03756
(603) 653-6059


Medical College of Wisconsin
8701 Watertown Plank Rd, Milwaukee, WI 53226
(414) 955-8486 jkramer@mcw.edu

New York City

Children's Hospital at Montefiore Medical Center
111 East 210th Street, New York City, NY 10467

New York City

ICAHN School of Medicine at Mount Sinai
1 Gustave L. Levy Place, New York City, NY 10029
212-241-9089 or 212-241-5177


Maine Center for Diabetes
887 Congress Street, Portland, ME 04102


Mid-Hudson Medical Group
30 Columbia Street, Poughkeepsie, NY 12601
(845) 202-6059


Rhode Island Hospital
593 Eddy St, Providence, RI 02903
401 444-8049


The Children's Hospital Baystate Med Center
50 Wason Ave, Springfield, MA 01199
(413) 794-1466


UMass Memorial Medical Center
UMMHC, 55 Lake Ave N, Worcester, MA 01655

Research Studies

Risk Screening

Pathway to Prevention

If you have a relative with T1D, you’re in a unique position to help us learn more about the disease and how to stop it. The first step is to sign up for Pathway to Prevention screening to determine your risk of developing T1D.


Prevention Study


TrialNet is testing the drug abatacept to see if it can delay or prevent progression of early stage T1D (stage 1 to stage 2) and ultimately prevent clinical diagnosis (stage 3). In earlier studies for people newly diagnosed (stage 3), abatacept helped slow down disease progression.



We are testing the drug teplizumab to see if it can delay or prevent progression of early stage T1D (stage 2) and prevent clinical diagnosis (stage 3). In earlier studies in people newly diagnosed (stage 3), teplizumab helped to prolong insulin production.



Long-Term Investigative Follow-Up in TrialNet (LIFT)

Once your study ends, we're still here for you. Participant monitoring and continued involvement helps us learn more about T1D.